منابع مشابه
Organization of DNA in chromatin ( chromatin structure / intercalation / DNA - kinking )
Conformational changes in DNA that accompany drug intercalation have led us to ask if DNA first bends or "kinks" to accept an intercalative drug or dye. Kinking is made possible by altering the normal C2' endo deoxyribose sugar ring puckering in B DNA to a mixed sugarpuckering pattern of the type C3' endo (3'-5') C2' endo and partially unstacking base-pairs. A kinking scheme such as this would ...
متن کاملAnalysis of chromatin integrity and DNA damage of buffalo spermatozoa
This study was conducted to determine chromatin integrity and DNA damage by DNA electrophoresis and comet assays of buffalo fresh and frozen semen. Semen samples were collected from four buffalo bulls and evaluated after freezing for semen motility, viability, sperm abnormalities, chromatin integrity and DNA damage. A significant variation was found in semen parameters after thawing. Highly sig...
متن کاملChromatin structure of adenovirus DNA throughout infection
For more than half a century, researchers have studied the basic biology of Adenovirus (Ad), unraveling the subtle, yet profound, interactions between the virus and the host. These studies have uncovered previously unknown proteins and pathways crucial for normal cell function that the virus manipulates to achieve optimal virus replication and gene expression. In the infecting virion, the viral...
متن کاملEffect of DNA methylation and chromatin structure on ITGAL expression.
LFA-1 (CD11a/CD18, alpha L beta 2) is an integrin expressed in a tissue-specific fashion and is important in inflammatory and immune responses. Promoter analysis has identified transcription factors that may be involved in CD11a expression, but the mechanisms contributing to its tissue-specific expression are incompletely characterized. In this report we have asked if DNA methylation and/or chr...
متن کاملOn the Relationship between DNA Periodicity and Local Chromatin Structure
DNA periodicity and its relationship to the formation of nucleosomes has been investigated extensively using autocorrelation and Fourier transform methods. We provide a precise treatment of the mathematical foundation for this type of analysis, and we apply the resulting method to quantify dinucleotide periodicity in several datasets. We begin by demonstrating, via simulation, the sensitivity o...
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ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 1996
ISSN: 1360-9947,1460-2407
DOI: 10.1093/molehr/2.7.481